Ontology highlight
ABSTRACT:
SUBMITTER: Wang B
PROVIDER: S-EPMC3704161 | biostudies-literature | 2008 May
REPOSITORIES: biostudies-literature
Cell metabolism 20080501 5
In fasted mammals, glucose homeostasis is maintained through induction of the cAMP response element-binding protein (CREB) coactivator transducer of regulated CREB activity 2 (TORC2), which stimulates the gluconeogenic program in concert with the forkhead factor FOXO1. Here we show that starvation also triggers TORC activation in Drosophila, where it maintains energy balance through induction of CREB target genes in the brain. TORC mutant flies have reduced glycogen and lipid stores and are sens ...[more]