Ontology highlight
ABSTRACT:
SUBMITTER: Napolitano F
PROVIDER: S-EPMC3704944 | biostudies-literature | 2013 Jun
REPOSITORIES: biostudies-literature
Napolitano Francesco F Zhao Yan Y Moreira Vânia M VM Tagliaferri Roberto R Kere Juha J D'Amato Mauro M Greco Dario D
Journal of cheminformatics 20130622 1
: Existing computational methods for drug repositioning either rely only on the gene expression response of cell lines after treatment, or on drug-to-disease relationships, merging several information levels. However, the noisy nature of the gene expression and the scarcity of genomic data for many diseases are important limitations to such approaches. Here we focused on a drug-centered approach by predicting the therapeutic class of FDA-approved compounds, not considering data concerning the di ...[more]