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Big steps toward understanding dynein.

ABSTRACT: Dynein is a microtubule-based molecular motor that is involved in various biological functions, such as axonal transport, mitosis, and cilia/flagella movement. Although dynein was discovered 50 years ago, the progress of dynein research has been slow due to its large size and flexible structure. Recent progress in understanding the force-generating mechanism of dynein using x-ray crystallography, cryo-electron microscopy, and single molecule studies has provided key insight into the structure and mechanism of action of this complex motor protein.

SUBMITTER: Kikkawa M

PROVIDER: S-EPMC3704981 | biostudies-literature | 2013 Jul

REPOSITORIES: biostudies-literature

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Big steps toward understanding dynein.

Kikkawa Masahide M

The Journal of cell biology 20130701 1

Dynein is a microtubule-based molecular motor that is involved in various biological functions, such as axonal transport, mitosis, and cilia/flagella movement. Although dynein was discovered 50 years ago, the progress of dynein research has been slow due to its large size and flexible structure. Recent progress in understanding the force-generating mechanism of dynein using x-ray crystallography, cryo-electron microscopy, and single molecule studies has provided key insight into the structure an ...[more]

PMID: 23836927

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