Ontology highlight
ABSTRACT:
SUBMITTER: Lloyd SE
PROVIDER: S-EPMC3705206 | biostudies-literature | 2013 Jun
REPOSITORIES: biostudies-literature
Current opinion in genetics & development 20130319 3
Prion diseases are transmissible, fatal neurodegenerative diseases that include scrapie and bovine spongiform encephalopathy (BSE) in animals and Creutzfeldt-Jakob disease (CJD) in human. The prion protein gene (PRNP) is the major genetic determinant of susceptibility, however, several studies now suggest that other genes are also important. Two recent genome wide association studies in human have identified four new loci of interest: ZBTB38-RASA2 in UK CJD cases and MTMR7 and NPAS2 in variant C ...[more]