Ontology highlight
ABSTRACT:
SUBMITTER: Bua DJ
PROVIDER: S-EPMC3705588 | biostudies-literature | 2013
REPOSITORIES: biostudies-literature
Scientific reports 20130101
ING2 (inhibitor of growth family member 2) is a component of a chromatin-regulatory complex that represses gene expression and is implicated in cellular processes that promote tumor suppression. However, few direct genomic targets of ING2 have been identified and the mechanism(s) by which ING2 selectively regulates genes remains unknown. Here we provide evidence that direct association of ING2 with the nuclear phosphoinositide phosphatidylinositol-5-phosphate (PtdIns(5)P) regulates a subset of I ...[more]