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The type II secretion system: biogenesis, molecular architecture and mechanism.

ABSTRACT: Many gram-negative bacteria use the sophisticated type II secretion system (T2SS) to translocate a wide range of proteins from the periplasm across the outer membrane. The inner-membrane platform of the T2SS is the nexus of the system and orchestrates the secretion process through its interactions with the periplasmic filamentous pseudopilus, the dodecameric outer-membrane complex and a cytoplasmic secretion ATPase. Here, recent structural and biochemical information is reviewed to describe our current knowledge of the biogenesis and architecture of the T2SS and its mechanism of action.

SUBMITTER: Korotkov KV

PROVIDER: S-EPMC3705712 | biostudies-literature | 2012 Apr

REPOSITORIES: biostudies-literature

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The type II secretion system: biogenesis, molecular architecture and mechanism.

Korotkov Konstantin V KV Sandkvist Maria M Hol Wim G J WG

Nature reviews. Microbiology 20120402 5

Many gram-negative bacteria use the sophisticated type II secretion system (T2SS) to translocate a wide range of proteins from the periplasm across the outer membrane. The inner-membrane platform of the T2SS is the nexus of the system and orchestrates the secretion process through its interactions with the periplasmic filamentous pseudopilus, the dodecameric outer-membrane complex and a cytoplasmic secretion ATPase. Here, recent structural and biochemical information is reviewed to describe our ...[more]

PMID: 22466878

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Dataset Information

The type II secretion system: biogenesis, molecular architecture and mechanism.

Publications

The type II secretion system: biogenesis, molecular architecture and mechanism.

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