Ontology highlight
ABSTRACT:
SUBMITTER: Koontz LM
PROVIDER: S-EPMC3705890 | biostudies-literature | 2013 May
REPOSITORIES: biostudies-literature
Koontz Laura M LM Liu-Chittenden Yi Y Yin Feng F Zheng Yonggang Y Yu Jianzhong J Huang Bo B Chen Qian Q Wu Shian S Pan Duojia D
Developmental cell 20130501 4
The Hippo tumor suppressor pathway restricts tissue growth by inactivating the transcriptional coactivator Yki. Although Sd has been implicated as a DNA-binding transcription factor partner for Yki and can genetically account for gain-of-function Yki phenotypes, how Yki regulates normal tissue growth remains a long-standing puzzle because Sd, unlike Yki, is dispensable for normal growth in most Drosophila tissues. Here we show that the yki mutant phenotypes in multiple developmental contexts are ...[more]