Crystal structure of a monomeric retroviral protease solved by protein folding game players.
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ABSTRACT:
SUBMITTER: Khatib F
PROVIDER: S-EPMC3705907 | biostudies-literature | 2011 Sep
REPOSITORIES: biostudies-literature
Publications
Crystal structure of a monomeric retroviral protease solved by protein folding game players.
Khatib Firas F DiMaio Frank F Cooper Seth S Kazmierczyk Maciej M Gilski Miroslaw M Krzywda Szymon S Zabranska Helena H Pichova Iva I Thompson James J Popović Zoran Z Jaskolski Mariusz M Baker David D
Nature structural & molecular biology 20110918 10
Following the failure of a wide range of attempts to solve the crystal structure of M-PMV retroviral protease by molecular replacement, we challenged players of the protein folding game Foldit to produce accurate models of the protein. Remarkably, Foldit players were able to generate models of sufficient quality for successful molecular replacement and subsequent structure determination. The refined structure provides new insights for the design of antiretroviral drugs. ...[more]
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