Ontology highlight
ABSTRACT:
SUBMITTER: Macauley MS
PROVIDER: S-EPMC3706185 | biostudies-literature | 2013 Jul
REPOSITORIES: biostudies-literature
Macauley Matthew S MS Pfrengle Fabian F Rademacher Christoph C Nycholat Corwin M CM Gale Andrew J AJ von Drygalski Annette A Paulson James C JC
The Journal of clinical investigation 20130603 7
Antibodies confer humoral immunity but can also be harmful when they target an autoantigen, alloantigen, allergen, or biotherapeutic. New strategies are needed for antigen-specific suppression of undesired antibody responses, particularly to T cell-dependent protein antigens, because they elicit T cell help. Here we show that liposomal nanoparticles, displaying both antigen and glycan ligands of the inhibitory coreceptor CD22, induce a tolerogenic program that selectively causes apoptosis in mou ...[more]