Ontology highlight
ABSTRACT:
SUBMITTER: Fruhbeis C
PROVIDER: S-EPMC3706306 | biostudies-literature | 2013 Jul
REPOSITORIES: biostudies-literature
Frühbeis Carsten C Fröhlich Dominik D Kuo Wen Ping WP Amphornrat Jesa J Thilemann Sebastian S Saab Aiman S AS Kirchhoff Frank F Möbius Wiebke W Goebbels Sandra S Nave Klaus-Armin KA Schneider Anja A Simons Mikael M Klugmann Matthias M Trotter Jacqueline J Krämer-Albers Eva-Maria EM
PLoS biology 20130709 7
Reciprocal interactions between neurons and oligodendrocytes are not only crucial for myelination, but also for long-term survival of axons. Degeneration of axons occurs in several human myelin diseases, however the molecular mechanisms of axon-glia communication maintaining axon integrity are poorly understood. Here, we describe the signal-mediated transfer of exosomes from oligodendrocytes to neurons. These endosome-derived vesicles are secreted by oligodendrocytes and carry specific protein a ...[more]