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New and emerging combination therapies for esophageal cancer.

ABSTRACT: Esophageal cancer comprises two different histological forms - squamous cell carcinoma (SCC) and adenocarcinoma (AC). While the incidence of AC has increased steeply in Western countries during the last few years, the incidence of SCC is fairly stable. Both forms differ in pathogenesis and response to chemotherapy and radiation therapy. Plenty of studies have evaluated new chemotherapy combination regimens in the neoadjuvant, adjuvant, and palliative setting. In addition, new radiation and chemoradiation protocols have been investigated. Finally, molecular-targeted therapy has been included in several new randomized prospective trials. Therefore, this review presents new data on this topic and critically discusses promising approaches towards a more effective treatment in a disease with a grim prognosis.

SUBMITTER: Wiedmann MW

PROVIDER: S-EPMC3706320 | biostudies-literature | 2013

REPOSITORIES: biostudies-literature

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New and emerging combination therapies for esophageal cancer.

Wiedmann Marcus W MW Mössner Joachim J

Cancer management and research 20130627

Esophageal cancer comprises two different histological forms - squamous cell carcinoma (SCC) and adenocarcinoma (AC). While the incidence of AC has increased steeply in Western countries during the last few years, the incidence of SCC is fairly stable. Both forms differ in pathogenesis and response to chemotherapy and radiation therapy. Plenty of studies have evaluated new chemotherapy combination regimens in the neoadjuvant, adjuvant, and palliative setting. In addition, new radiation and chemo ...[more]

PMID: 23869177

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Dataset Information

New and emerging combination therapies for esophageal cancer.

Publications

New and emerging combination therapies for esophageal cancer.

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