Ontology highlight
ABSTRACT:
SUBMITTER: Jeong SJ
PROVIDER: S-EPMC3706371 | biostudies-literature | 2013
REPOSITORIES: biostudies-literature
PloS one 20130709 7
Loss of function mutations in GPR56, which encodes a G protein-coupled receptor, cause a specific human brain malformation called bilateral frontoparietal polymicrogyria (BFPP). Studies from BFPP postmortem brain tissue and Gpr56 knockout mice have previously showed that GPR56 deletion leads to breaches in the pial basement membrane (BM) and neuronal ectopias during cerebral cortical development. Since α3β1 integrin also plays a role in pial BM assembly and maintenance, we evaluated whether it f ...[more]