In vivo function and evolution of the eutherian-specific pluripotency marker UTF1.
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ABSTRACT:
SUBMITTER: Nishimoto M
PROVIDER: S-EPMC3706607 | biostudies-literature | 2013
REPOSITORIES: biostudies-literature
Publications
In vivo function and evolution of the eutherian-specific pluripotency marker UTF1.
Nishimoto Masazumi M Katano Miyuki M Yamagishi Toshiyuki T Hishida Tomoaki T Kamon Masayoshi M Suzuki Ayumu A Hirasaki Masataka M Nabeshima Yoko Y Nabeshima Yo-ichi Y Katsura Yukako Y Satta Yoko Y Deakin Janine E JE Graves Jennifer A Marshall JA Kuroki Yoko Y Ono Ryuichi R Ishino Fumitoshi F Ema Masatsugu M Takahashi Satoru S Kato Hidemasa H Okuda Akihiko A
PloS one 20130709 7
Embryogenesis in placental mammals is sustained by exquisite interplay between the embryo proper and placenta. UTF1 is a developmentally regulated gene expressed in both cell lineages. Here, we analyzed the consequence of loss of the UTF1 gene during mouse development. We found that homozygous UTF1 mutant newborn mice were significantly smaller than wild-type or heterozygous mutant mice, suggesting that placental insufficiency caused by the loss of UTF1 expression in extra-embryonic ectodermal c ...[more]
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