Ontology highlight
ABSTRACT:
SUBMITTER: Yu XM
PROVIDER: S-EPMC3706783 | biostudies-literature | 2013 May
REPOSITORIES: biostudies-literature
Neuron 20130501 3
Axon pruning during development is essential for proper wiring of the mature nervous system, but its regulation remains poorly understood. We have identified an immunoglobulin superfamily (IgSF) transmembrane protein, Plum, that is cell autonomously required for axon pruning of mushroom body (MB) γ neurons and for ectopic synapse refinement at the developing neuromuscular junction in Drosophila. Plum promotes MB γ neuron axon pruning by regulating the expression of Ecdysone Receptor-B1, a key in ...[more]