Identification and MS-assisted interpretation of genetically influenced NMR signals in human plasma.
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ABSTRACT:
SUBMITTER: Raffler J
PROVIDER: S-EPMC3706909 | biostudies-literature | 2013
REPOSITORIES: biostudies-literature
Publications
Identification and MS-assisted interpretation of genetically influenced NMR signals in human plasma.
Raffler Johannes J Römisch-Margl Werner W Petersen Ann-Kristin AK Pagel Philipp P Blöchl Florian F Hengstenberg Christian C Illig Thomas T Meisinger Christa C Stark Klaus K Wichmann H-Erich HE Adamski Jerzy J Gieger Christian C Kastenmüller Gabi G Suhre Karsten K
Genome medicine 20130215 2
Nuclear magnetic resonance spectroscopy (NMR) provides robust readouts of many metabolic parameters in one experiment. However, identification of clinically relevant markers in (1)H NMR spectra is a major challenge. Association of NMR-derived quantities with genetic variants can uncover biologically relevant metabolic traits. Using NMR data of plasma samples from 1,757 individuals from the KORA study together with 655,658 genetic variants, we show that ratios between NMR intensities at two chemi ...[more]
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