Genome-wide approaches for identifying genetic risk factors for osteoporosis.
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ABSTRACT:
SUBMITTER: Wu S
PROVIDER: S-EPMC3706967 | biostudies-literature | 2013
REPOSITORIES: biostudies-literature
Publications
Genome-wide approaches for identifying genetic risk factors for osteoporosis.
Wu Shuyan S Liu Yongjun Y Zhang Lei L Han Yingying Y Lin Yong Y Deng Hong-Wen HW
Genome medicine 20130529 5
Osteoporosis, the most common type of bone disease worldwide, is clinically characterized by low bone mineral density (BMD) and increased susceptibility to fracture. Multiple genetic and environmental factors and gene-environment interactions have been implicated in its pathogenesis. Osteoporosis has strong genetic determination, with the heritability of BMD estimated to be as high as 60%. More than 80 genes or genetic variants have been implicated in risk of osteoporosis by hypothesis-free geno ...[more]
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