Unknown

Dataset Information

0

Genome-wide approaches for identifying genetic risk factors for osteoporosis.


ABSTRACT: Osteoporosis, the most common type of bone disease worldwide, is clinically characterized by low bone mineral density (BMD) and increased susceptibility to fracture. Multiple genetic and environmental factors and gene-environment interactions have been implicated in its pathogenesis. Osteoporosis has strong genetic determination, with the heritability of BMD estimated to be as high as 60%. More than 80 genes or genetic variants have been implicated in risk of osteoporosis by hypothesis-free genome-wide studies. However, these genes or genetic variants can only explain a small portion of BMD variation, suggesting that many other genes or genetic variants underlying osteoporosis risk await discovery. Here, we review recent progress in genome-wide studies of osteoporosis and discuss their implications for medicine and the major challenges in the field.

SUBMITTER: Wu S 

PROVIDER: S-EPMC3706967 | biostudies-literature | 2013

REPOSITORIES: biostudies-literature

altmetric image

Publications

Genome-wide approaches for identifying genetic risk factors for osteoporosis.

Wu Shuyan S   Liu Yongjun Y   Zhang Lei L   Han Yingying Y   Lin Yong Y   Deng Hong-Wen HW  

Genome medicine 20130529 5


Osteoporosis, the most common type of bone disease worldwide, is clinically characterized by low bone mineral density (BMD) and increased susceptibility to fracture. Multiple genetic and environmental factors and gene-environment interactions have been implicated in its pathogenesis. Osteoporosis has strong genetic determination, with the heritability of BMD estimated to be as high as 60%. More than 80 genes or genetic variants have been implicated in risk of osteoporosis by hypothesis-free geno  ...[more]

Similar Datasets

| S-EPMC3716448 | biostudies-literature
| S-EPMC8364821 | biostudies-literature
| S-EPMC4447004 | biostudies-literature
| S-EPMC2643048 | biostudies-literature
| S-EPMC3931553 | biostudies-literature
| S-EPMC5949092 | biostudies-literature
| S-EPMC7722161 | biostudies-literature
| S-EPMC4298800 | biostudies-literature
| S-EPMC6120117 | biostudies-literature
| S-EPMC3895629 | biostudies-literature