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Polyketides from a marine-derived fungus Xylariaceae sp.


ABSTRACT: Eighteen polyketides (1-18) including six citrinin derivatives, two phenol derivatives, one cyclopentenone, two naphthol derivatives, and seven tetralone derivatives were isolated from the culture broth of a marine-derived fungal strain Xylariaceae sp. SCSGAF0086. Five of these compounds (1, 2, 8, 9, and 10) were new, and their structures were determined by spectroscopic methods. Compounds 4, 6, 7, and 17 showed enzyme-inhibitory activities towards several tested enzymes, and 6 and 7 showed strong antifouling activity against Bugula neritina larvae settlement. This is the first time that the antifouling and enzyme-inhibitory activities of these compounds has been reported.

SUBMITTER: Nong XH 

PROVIDER: S-EPMC3707170 | biostudies-literature | 2013 May

REPOSITORIES: biostudies-literature

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Polyketides from a marine-derived fungus Xylariaceae sp.

Nong Xu-Hua XH   Zheng Zhi-Hui ZH   Zhang Xiao-Yong XY   Lu Xin-Hua XH   Qi Shu-Hua SH  

Marine drugs 20130521 5


Eighteen polyketides (1-18) including six citrinin derivatives, two phenol derivatives, one cyclopentenone, two naphthol derivatives, and seven tetralone derivatives were isolated from the culture broth of a marine-derived fungal strain Xylariaceae sp. SCSGAF0086. Five of these compounds (1, 2, 8, 9, and 10) were new, and their structures were determined by spectroscopic methods. Compounds 4, 6, 7, and 17 showed enzyme-inhibitory activities towards several tested enzymes, and 6 and 7 showed stro  ...[more]

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