Ontology highlight
ABSTRACT:
SUBMITTER: Meyer NJ
PROVIDER: S-EPMC3707367 | biostudies-literature | 2013 May
REPOSITORIES: biostudies-literature
Meyer Nuala J NJ Feng Rui R Li Mingyao M Zhao Yang Y Sheu Chau-Chyun CC Tejera Paula P Gallop Robert R Bellamy Scarlett S Rushefski Melanie M Lanken Paul N PN Aplenc Richard R O'Keefe Grant E GE Wurfel Mark M MM Christiani David C DC Christie Jason D JD
American journal of respiratory and critical care medicine 20130501 9
<h4>Rationale</h4>Acute respiratory distress syndrome (ARDS) behaves as a complex genetic trait, yet knowledge of genetic susceptibility factors remains incomplete.<h4>Objectives</h4>To identify genetic risk variants for ARDS using large scale genotyping.<h4>Methods</h4>A multistage genetic association study was conducted of three critically ill populations phenotyped for ARDS. Stage I, a trauma cohort study (n = 224), was genotyped with a 50K gene-centric single-nucleotide polymorphism (SNP) ar ...[more]