Ontology highlight
ABSTRACT:
SUBMITTER: Lecuona E
PROVIDER: S-EPMC3707378 | biostudies-literature | 2013 May
REPOSITORIES: biostudies-literature
Lecuona Emilia E Sun Haiying H Chen Jiwang J Trejo Humberto E HE Baker Margaret A MA Sznajder Jacob I JI
American journal of respiratory cell and molecular biology 20130501 5
Elevated concentrations of CO2 (hypercapnia) lead to alveolar epithelial dysfunction by promoting Na,K-ATPase endocytosis. In the present report, we investigated whether the CO2/HCO3(-) activated soluble adenylyl cyclase (sAC) regulates this process. We found that hypercapnia increased the production of cyclic adenosine monophosphate (cAMP) and stimulated protein kinase A (PKA) activity via sAC, which was necessary for Na,K-ATPase endocytosis. During hypercapnia, cAMP was mainly produced in spec ...[more]