Ontology highlight
ABSTRACT:
SUBMITTER: Wang X
PROVIDER: S-EPMC3707929 | biostudies-literature | 2011 Apr
REPOSITORIES: biostudies-literature
Wang Xiangfeng X Laurie John D JD Liu Tao T Wentz Jacqueline J Liu X Shirley XS
Genomics 20110202 4
The profiling of small RNAs by high-throughput sequencing (smRNA-Seq) has revealed the complexity of the RNA world. Here, we describe a computational scheme for dissecting the plant smRNAome by integrating smRNA-Seq datasets in Arabidopsis thaliana. Our analytical approach first defines ab initio the genomic loci that produce smRNAs as basic units, then utilizes principal component analysis (PCA) to predict novel miRNAs. Secondary structure prediction of candidates' putative precursors discovere ...[more]