Ontology highlight
ABSTRACT:
SUBMITTER: Sabarinathan R
PROVIDER: S-EPMC3708107 | biostudies-literature | 2013 Apr
REPOSITORIES: biostudies-literature
Sabarinathan Radhakrishnan R Tafer Hakim H Seemann Stefan E SE Hofacker Ivo L IL Stadler Peter F PF Gorodkin Jan J
Human mutation 20130401 4
Structural characteristics are essential for the functioning of many noncoding RNAs and cis-regulatory elements of mRNAs. SNPs may disrupt these structures, interfere with their molecular function, and hence cause a phenotypic effect. RNA folding algorithms can provide detailed insights into structural effects of SNPs. The global measures employed so far suffer from limited accuracy of folding programs on large RNAs and are computationally too demanding for genome-wide applications. Here, we pre ...[more]