Ontology highlight
ABSTRACT:
SUBMITTER: Schellenberg GD
PROVIDER: S-EPMC3708460 | biostudies-literature | 2012 Sep
REPOSITORIES: biostudies-literature
Schellenberg Gerard D GD Montine Thomas J TJ
Acta neuropathologica 20120523 3
Here we review the genetic causes and risks for Alzheimer's disease (AD). Early work identified mutations in three genes that cause AD: APP, PSEN1 and PSEN2. Although mutations in these genes are rare causes of AD, their discovery had a major impact on our understanding of molecular mechanisms of AD. Early work also revealed the ε4 allele of the APOE as a strong risk factor for AD. Subsequently, SORL1 also was identified as an AD risk gene. More recently, advances in our knowledge of the human g ...[more]