Tamoxifen induces rapid, reversible atrophy, and metaplasia in mouse stomach.
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ABSTRACT:
SUBMITTER: Huh WJ
PROVIDER: S-EPMC3708546 | biostudies-literature | 2012 Jan
REPOSITORIES: biostudies-literature
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Tamoxifen induces rapid, reversible atrophy, and metaplasia in mouse stomach.
Huh Won Jae WJ Khurana Shradha S SS Geahlen Jessica H JH Kohli Kavita K Waller Rachel A RA Mills Jason C JC
Gastroenterology 20111014 1
Tamoxifen, a selective estrogen receptor modulator, is widely used in research and clinically in patients. We find that treatment of normal mice with a single ≥3 mg/20 g body weight dose of tamoxifen leads to apoptosis of >90% of all gastric parietal cells (PCs) and metaplasia of zymogenic chief cells within 3 days. Remarkably, gastric histology returns to nearly normal by 3 weeks. Tamoxifen toxicity occurs by oral and intraperitoneal administration, in both sexes, in multiple strains, and does ...[more]
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