Ontology highlight
ABSTRACT:
SUBMITTER: Liu W
PROVIDER: S-EPMC3708806 | biostudies-literature | 2013
REPOSITORIES: biostudies-literature
Liu Weiyi W Bi Pengpeng P Shan Tizhong T Yang Xin X Yin Hang H Wang Yong-Xu YX Liu Ning N Rudnicki Michael A MA Kuang Shihuan S
PLoS genetics 20130711 7
Prdm16 determines the bidirectional fate switch of skeletal muscle/brown adipose tissue (BAT) and regulates the thermogenic gene program of subcutaneous white adipose tissue (SAT) in mice. Here we show that miR-133a, a microRNA that is expressed in both BAT and SATs, directly targets the 3' UTR of Prdm16. The expression of miR-133a dramatically decreases along the commitment and differentiation of brown preadipocytes, accompanied by the upregulation of Prdm16. Overexpression of miR-133a in BAT a ...[more]