Ontology highlight
ABSTRACT:
SUBMITTER: Hu YC
PROVIDER: S-EPMC3708810 | biostudies-literature | 2013
REPOSITORIES: biostudies-literature
Hu Yueh-Chiang YC Okumura Leah M LM Page David C DC
PLoS genetics 20130711 7
In mammals, both testis and ovary arise from a sexually undifferentiated precursor, the genital ridge, which first appears during mid-gestation as a thickening of the coelomic epithelium on the ventromedial surface of the mesonephros. At least four genes (Lhx9, Sf1, Wt1, and Emx2) have been demonstrated to be required for subsequent growth and maintenance of the genital ridge. However, no gene has been shown to be required for the initial thickening of the coelomic epithelium during genital ridg ...[more]