Ontology highlight
ABSTRACT:
SUBMITTER: Drechsler M
PROVIDER: S-EPMC3708815 | biostudies-literature | 2013
REPOSITORIES: biostudies-literature
Drechsler Maik M Schmidt Ariane C AC Meyer Heiko H Paululat Achim A
PLoS genetics 20130711 7
Here we report on the identification and functional characterization of the ADAMTS-like homolog lonely heart (loh) in Drosophila melanogaster. Loh displays all hallmarks of ADAMTSL proteins including several thrombospondin type 1 repeats (TSR1), and acts in concert with the collagen Pericardin (Prc). Loss of either loh or prc causes progressive cardiac damage peaking in the abolishment of heart function. We show that both proteins are integral components of the cardiac ECM mediating cellular adh ...[more]