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Does exposure to stressors predict changes in physiological dysregulation?

ABSTRACT: The allostatic load framework implies that cumulative exposure to stressors results in multi-system physiological dysregulation.The purpose of this study was to investigate the effect of stress burden on subsequent changes (2000-2006) in physiological dysregulation.Data came from a population-based cohort study in Taiwan (n?=?521, aged 54+ in 2000, re-examined in 2006). Measures of stressful events and chronic strain were based on questions asked in 1996, 1999, and 2000. A measure of trauma was based on exposure to the 1999 earthquake. Dysregulation was based on 17 biomarkers (e.g., metabolic, inflammatory, neuroendocrine).There were some small effects among men: chronic strain was associated with subsequent increases in dysregulation (standardized ??=?0.08, 95 % CI?=?0.01 to 0.20), particularly inflammation; life events were also associated with increased inflammation (??=?0.10, CI?=?0.01 to 0.26). There were no significant effects in women.We found weak evidence that stress burden is associated with changes in dysregulation.

SUBMITTER: Glei DA

PROVIDER: S-EPMC3708988 | biostudies-literature | 2013 Aug

REPOSITORIES: biostudies-literature

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Does exposure to stressors predict changes in physiological dysregulation?

Glei Dana A DA Goldman Noreen N Wu Chih-Hsun CH Weinstein Maxine M

Annals of behavioral medicine : a publication of the Society of Behavioral Medicine 20130801 1

<h4>Background</h4>The allostatic load framework implies that cumulative exposure to stressors results in multi-system physiological dysregulation.<h4>Purpose</h4>The purpose of this study was to investigate the effect of stress burden on subsequent changes (2000-2006) in physiological dysregulation.<h4>Methods</h4>Data came from a population-based cohort study in Taiwan (n = 521, aged 54+ in 2000, re-examined in 2006). Measures of stressful events and chronic strain were based on questions aske ...[more]

PMID: 23526059

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Project description:Although a growing literature describes the effects of negative childhood experiences on biological outcomes, it is difficult to compare results across studies because of differences in measures of childhood experiences, biological markers, sample characteristics, and included covariates. To ensure comparability across its analyses, this study used a single national survey of adults in the United States-the Midlife in the United States (MIDUS) study-to examine comprehensively the association between adverse childhood experiences, operationalized as childhood maltreatment (CM), and biological markers of risk for poor health and to assess whether these associations differ by type of maltreatment, sex, or race. The sample included 1254, mostly White (78%), adults aged 34-86 years (mean age 57 years), 57% of whom were female. We present incidence rate ratios (IRR) from negative binomial and Poisson regressions to examine the relationships between exposure to CM (emotional, physical, and sexual abuse; emotional and physical neglect; and a CM-index reflecting frequency across all five types of maltreatment) and four biological risk summary scores (overall physiological dysregulation, cardiometabolic risk, inflammation, and hypothalamic pituitary axis/sympathetic nervous system (HPA/SNS) function). We also tested whether the effect of each type of CM varied by sex and by race. The CM-index was associated with higher overall physiological dysregulation and inflammation, but the associations were weaker and not statistically significant for cardiometabolic risk and HPA/SNS function. With the exception of a possible sex difference in the association between sexual abuse and overall physiological dysregulation, there was little evidence that the associations varied systematically by type of CM or by sex or race. We conclude that exposure to CM predicts adult biological risk, particularly inflammation. Inconsistency with previous research suggests that additional research is needed to confirm findings regarding sex and race differences.

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Does exposure to stressors predict changes in physiological dysregulation?

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Does exposure to stressors predict changes in physiological dysregulation?

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