Common biological networks underlie genetic risk for alcoholism in African- and European-American populations.
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ABSTRACT:
SUBMITTER: Kos MZ
PROVIDER: S-EPMC3709451 | biostudies-literature | 2013 Jul
REPOSITORIES: biostudies-literature
Publications
Common biological networks underlie genetic risk for alcoholism in African- and European-American populations.
Kos M Z MZ Yan J J Dick D M DM Agrawal A A Bucholz K K KK Rice J P JP Johnson E O EO Schuckit M M Kuperman S S Kramer J J Goate A M AM Tischfield J A JA Foroud T T Nurnberger J J Hesselbrock V V Porjesz B B Bierut L J LJ Edenberg H J HJ Almasy L L
Genes, brain, and behavior 20130510 5
Alcohol dependence (AD) is a heritable substance addiction with adverse physical and psychological consequences, representing a major health and economic burden on societies worldwide. Genes thus far implicated via linkage, candidate gene and genome-wide association studies (GWAS) account for only a small fraction of its overall risk, with effects varying across ethnic groups. Here we investigate the genetic architecture of alcoholism and report on the extent to which common, genome-wide SNPs co ...[more]
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