Ontology highlight
ABSTRACT:
SUBMITTER: Cabrera SM
PROVIDER: S-EPMC3709459 | biostudies-literature | 2012 Dec
REPOSITORIES: biostudies-literature
Current molecular medicine 20121201 10
Type 1 diabetes mellitus (T1DM) is a T cell-mediated autoimmune disease resulting in islet β cell destruction, hypoinsulinemia, and severely altered glucose homeostasis. T1DM has classically been attributed to the pathogenic actions of auto-reactive effector T cells(Teffs) on the β cell. Recent literature now suggests that a failure of a second T cell subtype, known as regulatory T cells (Tregs), plays a critical role in the development of T1DM. During immune homeostasis, Tregs counterbalance th ...[more]