Picornavirus uncoating intermediate captured in atomic detail.
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ABSTRACT:
SUBMITTER: Ren J
PROVIDER: S-EPMC3709478 | biostudies-literature | 2013
REPOSITORIES: biostudies-literature
Publications
Picornavirus uncoating intermediate captured in atomic detail.
Ren Jingshan J Wang Xiangxi X Hu Zhongyu Z Gao Qiang Q Sun Yao Y Li Xuemei X Porta Claudine C Walter Thomas S TS Gilbert Robert J RJ Zhao Yuguang Y Axford Danny D Williams Mark M McAuley Katherine K Rowlands David J DJ Yin Weidong W Wang Junzhi J Stuart David I DI Rao Zihe Z Fry Elizabeth E EE
Nature communications 20130101
It remains largely mysterious how the genomes of non-enveloped eukaryotic viruses are transferred across a membrane into the host cell. Picornaviruses are simple models for such viruses, and initiate this uncoating process through particle expansion, which reveals channels through which internal capsid proteins and the viral genome presumably exit the particle, although this has not been clearly seen until now. Here we present the atomic structure of an uncoating intermediate for the major human ...[more]
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