Hypothalamic proteoglycan syndecan-3 is a novel cocaine addiction resilience factor.
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ABSTRACT:
SUBMITTER: Chen J
PROVIDER: S-EPMC3709481 | biostudies-literature | 2013
REPOSITORIES: biostudies-literature
Publications
Hypothalamic proteoglycan syndecan-3 is a novel cocaine addiction resilience factor.
Chen Jihuan J Repunte-Canonigo Vez V Kawamura Tomoya T Lefebvre Celine C Shin William W Howell Leonard L LL Hemby Scott E SE Harvey Brandon K BK Califano Andrea A Morales Marisela M Koob George F GF Sanna Pietro Paolo PP
Nature communications 20130101
Proteoglycans like syndecan-3 have complex signaling roles in addition to their function as structural components of the extracellular matrix. Here, we show that syndecan-3 in the lateral hypothalamus has an unexpected new role in limiting compulsive cocaine intake. In particular, we observe that syndecan-3 null mice self-administer greater amounts of cocaine than wild-type mice. This effect can be rescued by re-expression of syndecan-3 in the lateral hypothalamus with an adeno-associated viral ...[more]
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2006-01-26 | GSE3016 | GEO
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