Ontology highlight
ABSTRACT:
SUBMITTER: Muller TD
PROVIDER: S-EPMC3709495 | biostudies-literature | 2013
REPOSITORIES: biostudies-literature
Nature communications 20130101
The G protein-coupled receptor 83 (Gpr83) is widely expressed in brain regions regulating energy metabolism. Here we report that hypothalamic expression of Gpr83 is regulated in response to nutrient availability and is decreased in obese mice compared with lean mice. In the arcuate nucleus, Gpr83 colocalizes with the ghrelin receptor (Ghsr1a) and the agouti-related protein. In vitro analyses show heterodimerization of Gpr83 with Ghsr1a diminishes activation of Ghsr1a by acyl-ghrelin. The orexige ...[more]