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Integrating DNA strand-displacement circuitry with DNA tile self-assembly.

ABSTRACT: DNA nanotechnology has emerged as a reliable and programmable way of controlling matter at the nanoscale through the specificity of Watson-Crick base pairing, allowing both complex self-assembled structures with nanometer precision and complex reaction networks implementing digital and analog behaviors. Here we show how two well-developed frameworks, DNA tile self-assembly and DNA strand-displacement circuits, can be systematically integrated to provide programmable kinetic control of self-assembly. We demonstrate the triggered and catalytic isothermal self-assembly of DNA nanotubes over 10??m long from precursor DNA double-crossover tiles activated by an upstream DNA catalyst network. Integrating more sophisticated control circuits and tile systems could enable precise spatial and temporal organization of dynamic molecular structures.

SUBMITTER: Zhang DY

PROVIDER: S-EPMC3709499 | biostudies-literature | 2013

REPOSITORIES: biostudies-literature

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Integrating DNA strand-displacement circuitry with DNA tile self-assembly.

Zhang David Yu DY Hariadi Rizal F RF Choi Harry M T HM Winfree Erik E

Nature communications 20130101

DNA nanotechnology has emerged as a reliable and programmable way of controlling matter at the nanoscale through the specificity of Watson-Crick base pairing, allowing both complex self-assembled structures with nanometer precision and complex reaction networks implementing digital and analog behaviors. Here we show how two well-developed frameworks, DNA tile self-assembly and DNA strand-displacement circuits, can be systematically integrated to provide programmable kinetic control of self-assem ...[more]

PMID: 23756381

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