Specifying and sustaining pigmentation patterns in domestic and wild cats.
Ontology highlight
ABSTRACT:
SUBMITTER: Kaelin CB
PROVIDER: S-EPMC3709578 | biostudies-literature | 2012 Sep
REPOSITORIES: biostudies-literature
Publications
Specifying and sustaining pigmentation patterns in domestic and wild cats.
Kaelin Christopher B CB Xu Xiao X Hong Lewis Z LZ David Victor A VA McGowan Kelly A KA Schmidt-Küntzel Anne A Roelke Melody E ME Pino Javier J Pontius Joan J Cooper Gregory M GM Manuel Hermogenes H Swanson William F WF Marker Laurie L Harper Cindy K CK van Dyk Ann A Yue Bisong B Mullikin James C JC Warren Wesley C WC Eizirik Eduardo E Kos Lidia L O'Brien Stephen J SJ Barsh Gregory S GS Menotti-Raymond Marilyn M
Science (New York, N.Y.) 20120901 6101
Color markings among felid species display both a remarkable diversity and a common underlying periodicity. A similar range of patterns in domestic cats suggests a conserved mechanism whose appearance can be altered by selection. We identified the gene responsible for tabby pattern variation in domestic cats as Transmembrane aminopeptidase Q (Taqpep), which encodes a membrane-bound metalloprotease. Analyzing 31 other felid species, we identified Taqpep as the cause of the rare king cheetah pheno ...[more]
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