Human chorionic gonadotropin beta subunit genes CGB1 and CGB2 are transcriptionally active in ovarian cancer.
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ABSTRACT:
SUBMITTER: Kubiczak M
PROVIDER: S-EPMC3709805 | biostudies-literature | 2013
REPOSITORIES: biostudies-literature
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Human chorionic gonadotropin beta subunit genes CGB1 and CGB2 are transcriptionally active in ovarian cancer.
Kubiczak Marta M Walkowiak Grzegorz P GP Nowak-Markwitz Ewa E Jankowska Anna A
International journal of molecular sciences 20130617 6
Human chorionic gonadotropin beta subunit (CGB) is a marker of pregnancy as well as trophoblastic and nontrophoblastic tumors. CGB is encoded by a cluster of six genes, of which type II genes (CGB3/9, 5 and 8) have been shown to be upregulated in relation to type I genes (CGB6/7) in both placentas and tumors. Recent studies revealed that CGB1 and CGB2, originally considered as pseudogenes, might also be active, however, the protein products of these genes have not yet been identified. Our study ...[more]
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