Targeting NOX enzymes in pulmonary fibrosis.
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ABSTRACT:
SUBMITTER: Hecker L
PROVIDER: S-EPMC3710124 | biostudies-literature | 2012 Jul
REPOSITORIES: biostudies-literature
Publications
Targeting NOX enzymes in pulmonary fibrosis.
Hecker Louise L Cheng Jeff J Thannickal Victor J VJ
Cellular and molecular life sciences : CMLS 20120523 14
Oxidative stress has been associated with a number of human fibrotic diseases, including idiopathic pulmonary fibrosis (IPF). Oxidative stress is most often defined as an imbalance between the generation of reactive oxygen species (ROS) in excess of the capacity of cells/tissues to detoxify or scavenge them. Additionally, the regulated production of ROS participates in cellular signaling. Therapeutic strategies to treat IPF have, thus far, focused on augmenting anti-oxidant capacity. Recent stud ...[more]
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