Ontology highlight
ABSTRACT:
SUBMITTER: Lui VW
PROVIDER: S-EPMC3710532 | biostudies-literature | 2013 Jul
REPOSITORIES: biostudies-literature
Cancer discovery 20130425 7
Genomic findings underscore the heterogeneity of head and neck squamous cell carcinoma (HNSCC). Identification of mutations that predict therapeutic response would be a major advance. We determined the mutationally altered, targetable mitogenic pathways in a large HNSCC cohort. Analysis of whole-exome sequencing data from 151 tumors revealed the phosphoinositide 3-kinase (PI3K) pathway to be the most frequently mutated oncogenic pathway (30.5%). PI3K pathway-mutated HNSCC tumors harbored a signi ...[more]