Ontology highlight
ABSTRACT:
SUBMITTER: Buraschi S
PROVIDER: S-EPMC3710796 | biostudies-literature | 2013 Jul
REPOSITORIES: biostudies-literature
Buraschi Simone S Neill Thomas T Goyal Atul A Poluzzi Chiara C Smythies James J Owens Rick T RT Schaefer Liliana L Torres Annabel A Iozzo Renato V RV
Proceedings of the National Academy of Sciences of the United States of America 20130624 28
Soluble decorin affects the biology of several receptor tyrosine kinases by triggering receptor internalization and degradation. We found that decorin induced paternally expressed gene 3 (Peg3), an imprinted tumor suppressor gene, and that Peg3 relocated into autophagosomes labeled by Beclin 1 and microtubule-associated light chain 3. Decorin evoked Peg3-dependent autophagy in both microvascular and macrovascular endothelial cells leading to suppression of angiogenesis. Peg3 coimmunoprecipitated ...[more]