Unknown

Dataset Information

0

Treatment of Non-small Cell Lung Carcinoma after Failure of Epidermal Growth Factor Receptor Tyrosine Kinase Inhibitor.


ABSTRACT: Since the first description of non-small cell lung cancer (NSCLC) with activating epidermal growth factor receptor (EGFR) mutation as a distinct clinical entity, studies have proved EGFR tyrosine kinase inhibitors (TKIs) as a first choice of treatment. The median response duration of TKIs as a first-line treatment for EGFR mutant tumors ranges from 11 to 14 months. However, acquired resistance to EGFR-TKIs is inevitable due to various mechanisms, such as T790M, c-Met amplification, activation of alternative pathways (IGF-1, HGF, PI3CA, AXL), transformation to mesenchymal cell or small cell features, and tumor heterogeneity. Until development of a successful treatment strategy to overcome such acquired resistance, few options are currently available. Here we provide a summary of the therapeutic options after failure of first line EGFR-TKI treatment for NSCLC.

SUBMITTER: Lee JC 

PROVIDER: S-EPMC3710966 | biostudies-literature | 2013 Jun

REPOSITORIES: biostudies-literature

altmetric image

Publications

Treatment of Non-small Cell Lung Carcinoma after Failure of Epidermal Growth Factor Receptor Tyrosine Kinase Inhibitor.

Lee Jae Cheol JC   Jang Seung Hun SH   Lee Kye Young KY   Kim Young-Chul YC  

Cancer research and treatment 20130630 2


Since the first description of non-small cell lung cancer (NSCLC) with activating epidermal growth factor receptor (EGFR) mutation as a distinct clinical entity, studies have proved EGFR tyrosine kinase inhibitors (TKIs) as a first choice of treatment. The median response duration of TKIs as a first-line treatment for EGFR mutant tumors ranges from 11 to 14 months. However, acquired resistance to EGFR-TKIs is inevitable due to various mechanisms, such as T790M, c-Met amplification, activation of  ...[more]

Similar Datasets

| S-EPMC8833717 | biostudies-literature
| S-EPMC3589701 | biostudies-literature
| S-EPMC4129529 | biostudies-literature
| S-EPMC3712950 | biostudies-literature
| S-EPMC5329801 | biostudies-literature
| S-EPMC4367710 | biostudies-literature
| S-EPMC4982590 | biostudies-literature
| S-EPMC4753639 | biostudies-literature
| S-EPMC8247868 | biostudies-literature
| S-EPMC8195272 | biostudies-literature