Ontology highlight
ABSTRACT:
SUBMITTER: Millard CJ
PROVIDER: S-EPMC3710971 | biostudies-literature | 2013 Jul
REPOSITORIES: biostudies-literature
Millard Christopher J CJ Watson Peter J PJ Celardo Ivana I Gordiyenko Yuliya Y Cowley Shaun M SM Robinson Carol V CV Fairall Louise L Schwabe John W R JW
Molecular cell 20130620 1
Class I histone deacetylases (HDAC1, HDAC2, and HDAC3) are recruited by cognate corepressor proteins into specific transcriptional repression complexes that target HDAC activity to chromatin resulting in chromatin condensation and transcriptional silencing. We previously reported the structure of HDAC3 in complex with the SMRT corepressor. This structure revealed the presence of inositol-tetraphosphate [Ins(1,4,5,6)P4] at the interface of the two proteins. It was previously unclear whether the r ...[more]