Ontology highlight
ABSTRACT:
SUBMITTER: Akhtar-Zaidi B
PROVIDER: S-EPMC3711120 | biostudies-literature | 2012 May
REPOSITORIES: biostudies-literature
Akhtar-Zaidi Batool B Cowper-Sal-lari Richard R Corradin Olivia O Saiakhova Alina A Bartels Cynthia F CF Balasubramanian Dheepa D Myeroff Lois L Lutterbaugh James J Jarrar Awad A Kalady Matthew F MF Willis Joseph J Moore Jason H JH Tesar Paul J PJ Laframboise Thomas T Markowitz Sanford S Lupien Mathieu M Scacheri Peter C PC
Science (New York, N.Y.) 20120412 6082
Cancer is characterized by gene expression aberrations. Studies have largely focused on coding sequences and promoters, even though distal regulatory elements play a central role in controlling transcription patterns. We used the histone mark H3K4me1 to analyze gain and loss of enhancer activity genome-wide in primary colon cancer lines relative to normal colon crypts. We identified thousands of variant enhancer loci (VELs) that comprise a signature that is robustly predictive of the in vivo col ...[more]