Dynamics of self-assembly of model viral capsids in the presence of a fluctuating membrane.

ABSTRACT: A coarse-grained computational model is used to investigate the effect of a fluctuating fluid membrane on the dynamics of patchy-particle assembly into virus capsid-like cores. Results from simulations for a broad range of parameters are presented, showing the effect of varying interaction strength, membrane stiffness, and membrane viscosity. Furthermore, the effect of hydrodynamic interactions is investigated. Attraction to a membrane may promote assembly, including for subunit interaction strengths for which it does not occur in the bulk, and may also decrease single-core assembly time. The membrane budding rate is strongly increased by hydrodynamic interactions. The membrane deformation rate is important in determining the finite-time yield. Higher rates may decrease the entropic penalt

SUBMITTER: Matthews R 

PROVIDER: S-EPMC3711127 | biostudies-literature | 2013 Jul

REPOSITORIES: biostudies-literature