Ontology highlight
ABSTRACT:
SUBMITTER: Meinhardt MW
PROVIDER: S-EPMC3711176 | biostudies-literature | 2013 Feb
REPOSITORIES: biostudies-literature
Meinhardt Marcus W MW Hansson Anita C AC Perreau-Lenz Stephanie S Bauder-Wenz Christina C Stählin Oliver O Heilig Markus M Harper Clive C Drescher Karla U KU Spanagel Rainer R Sommer Wolfgang H WH
The Journal of neuroscience : the official journal of the Society for Neuroscience 20130201 7
A key deficit in alcohol dependence is disrupted prefrontal function leading to excessive alcohol seeking, but the molecular events underlying the emergence of addictive responses remain unknown. Here we show by convergent transcriptome analysis that the pyramidal neurons of the infralimbic cortex are particularly vulnerable for the long-term effects of chronic intermittent ethanol intoxication. These neurons exhibit a pronounced deficit in metabotropic glutamate receptor subtype 2 (mGluR(2)). A ...[more]