Ontology highlight
ABSTRACT:
SUBMITTER: Roland BP
PROVIDER: S-EPMC3711204 | biostudies-literature | 2013 Jul
REPOSITORIES: biostudies-literature
Roland Bartholomew P BP Stuchul Kimberly A KA Larsen Samantha B SB Amrich Christopher G CG Vandemark Andrew P AP Celotto Alicia M AM Palladino Michael J MJ
Journal of cell science 20130502 Pt 14
Triosephosphate isomerase (TPI) is a glycolytic enzyme that converts dihydroxyacetone phosphate (DHAP) into glyceraldehyde 3-phosphate (GAP). Glycolytic enzyme dysfunction leads to metabolic diseases collectively known as glycolytic enzymopathies. Of these enzymopathies, TPI deficiency is unique in the severity of neurological symptoms. The Drosophila sugarkill mutant closely models TPI deficiency and encodes a protein prematurely degraded by the proteasome. This led us to question whether enzym ...[more]