Sequencing of 50 human exomes reveals adaptation to high altitude.
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ABSTRACT:
SUBMITTER: Yi X
PROVIDER: S-EPMC3711608 | biostudies-literature | 2010 Jul
REPOSITORIES: biostudies-literature
Publications
Sequencing of 50 human exomes reveals adaptation to high altitude.
Yi Xin X Liang Yu Y Huerta-Sanchez Emilia E Jin Xin X Cuo Zha Xi Ping ZX Pool John E JE Xu Xun X Jiang Hui H Vinckenbosch Nicolas N Korneliussen Thorfinn Sand TS Zheng Hancheng H Liu Tao T He Weiming W Li Kui K Luo Ruibang R Nie Xifang X Wu Honglong H Zhao Meiru M Cao Hongzhi H Zou Jing J Shan Ying Y Li Shuzheng S Yang Qi Q Asan Ni Peixiang P Tian Geng G Xu Junming J Liu Xiao X Jiang Tao T Wu Renhua R Zhou Guangyu G Tang Meifang M Qin Junjie J Wang Tong T Feng Shuijian S Li Guohong G Huasang Luosang Jiangbai J Wang Wei W Chen Fang F Wang Yading Y Zheng Xiaoguang X Li Zhuo Z Bianba Zhuoma Z Yang Ge G Wang Xinping X Tang Shuhui S Gao Guoyi G Chen Yong Y Luo Zhen Z Gusang Lamu L Cao Zheng Z Zhang Qinghui Q Ouyang Weihan W Ren Xiaoli X Liang Huiqing H Zheng Huisong H Huang Yebo Y Li Jingxiang J Bolund Lars L Kristiansen Karsten K Li Yingrui Y Zhang Yong Y Zhang Xiuqing X Li Ruiqiang R Li Songgang S Yang Huanming H Nielsen Rasmus R Wang Jun J Wang Jian J
Science (New York, N.Y.) 20100701 5987
Residents of the Tibetan Plateau show heritable adaptations to extreme altitude. We sequenced 50 exomes of ethnic Tibetans, encompassing coding sequences of 92% of human genes, with an average coverage of 18x per individual. Genes showing population-specific allele frequency changes, which represent strong candidates for altitude adaptation, were identified. The strongest signal of natural selection came from endothelial Per-Arnt-Sim (PAS) domain protein 1 (EPAS1), a transcription factor involve ...[more]
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