Ontology highlight
ABSTRACT:
SUBMITTER: Huang M
PROVIDER: S-EPMC3711644 | biostudies-literature | 2012 May
REPOSITORIES: biostudies-literature
Huang M M Anand S S Murphy E A EA Desgrosellier J S JS Stupack D G DG Shattil S J SJ Schlaepfer D D DD Cheresh D A DA
Oncogene 20111003 22
Tyrosine kinase receptors have an essential role in various aspects of tumor progression. In particular, epidermal growth factor receptor (EGFR) and its ligands have been implicated in the growth and dissemination of a wide array of human carcinomas. Here, we describe an EGFR-mediated signaling pathway that regulates human pancreatic carcinoma cell invasion and metastasis, yet does not influence the growth of primary tumors. In fact, ligation/activation of EGFR induces Src-dependent phosphorylat ...[more]