Ontology highlight
ABSTRACT:
SUBMITTER: Reyes N
PROVIDER: S-EPMC3711778 | biostudies-literature | 2013 May
REPOSITORIES: biostudies-literature
Reyes Nicolas N Oh SeCheol S Boudker Olga O
Nature structural & molecular biology 20130407 5
Glutamate transporters catalyze concentrative uptake of the neurotransmitter into glial cells and neurons. Their transport cycle involves binding and release of the substrate on the extra- and intracellular sides of the plasma membranes and translocation of the substrate-binding site across the lipid bilayers. The energy of the ionic gradients, mainly sodium, fuels the cycle. Here, we used a cross-linking approach to trap a glutamate transporter homolog from Pyrococcus horikoshii in key conforma ...[more]