PolyIC GE11 polyplex inhibits EGFR-overexpressing tumors.
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ABSTRACT:
SUBMITTER: Abourbeh G
PROVIDER: S-EPMC3711802 | biostudies-literature | 2012 Apr
REPOSITORIES: biostudies-literature
Publications
PolyIC GE11 polyplex inhibits EGFR-overexpressing tumors.
Abourbeh Galith G Shir Alexei A Mishani Eyal E Ogris Manfred M Rödl Wolfgang W Wagner Ernst E Levitzki Alexander A
IUBMB life 20120223 4
Phage display has identified the dodecapeptide YHWYGYTPQNVI (GE11) as a ligand that binds to the epidermal growth factor receptor (EGFR) but does not activate the receptor. Here, we compare the EGFR binding affinities of GE11, EGF, and their polyethyleneimine-polyethyleneglycol (PEI-PEG) conjugates. We found that although GE11 by itself does not exhibit measurable affinity to the EGFR, tethering it to PEI-PEG increases its affinity markedly, and complex formation with polyinosine/cytosine (polyI ...[more]
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