Dataset Information

Caffeine intake, short bouts of physical activity, and energy expenditure: a double-blind randomized crossover trial.

ABSTRACT: PA energy expenditure (PAEE) is the most variable component of Total Energy Expenditure (TEE) and largely due to the balance of sedentary time (SedT) and low intensity physical activity (LIPA). There has been an emergence for seeking an understanding of factors which determine variations in SedT, LIPA, and PAEE. Sedentary behavior and physical activity are relatively resistant to change by experimental dietary treatments and significant body weight changes. Although caffeine (Caf) is by far the most heavily used nutritional agent ingested to promote a sense of vigor/alertness, it is still unknown if Caf is effective in increasing PAEE and physical activity. The aim of the study was to test the hypothesis that 2 daily doses of Caf (as a capsule to blind the treatment and divided equally during breakfast and lunch) increase PAEE and TEE, and it would do so through increasing the frequent and brief bouts of physical activity (~1-5 min long) through the day as measured by accelerometry. In 21 low Caf users (<100 mg day(-1)), we used a double-blind crossover trial (ClinicalTrials.govID;NCT01477294) with two conditions (4-day each with a 3-day washout period) randomly ordered as 5 mg kg(-1) day(-1) of Caf and maltodextrin as placebo (Plc). Resting energy expenditure (REE) by indirect calorimetry, total energy expenditure (TEE) from doubly labeled water, PAEE calculated as TEE-(REE+0.1TEE), and accelerometry measurements of both LIPA and MVPA were not different between conditions. However, regardless of caffeine or placebo, there were several significant relationships between brief bouts of LIPA and MVPA with PAEE. In conclusion, this double-blind study found that low and moderate-vigorous activity as well as the total volume of PAEE in free-living conditions is resistant to dietary caffeine intake that was equivalent to 5 cups of espresso or 7 cups of tea.ClinicalTrials.gov NCT01477294.

SUBMITTER: Judice PB

PROVIDER: S-EPMC3711911 | biostudies-literature | 2013

REPOSITORIES: biostudies-literature

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Caffeine intake, short bouts of physical activity, and energy expenditure: a double-blind randomized crossover trial.

Júdice Pedro B PB Matias Catarina N CN Santos Diana A DA Magalhães João P JP Hamilton Marc T MT Sardinha Luís B LB Silva Analiza M AM

PloS one 20130715 7

<h4>Unlabelled</h4>PA energy expenditure (PAEE) is the most variable component of Total Energy Expenditure (TEE) and largely due to the balance of sedentary time (SedT) and low intensity physical activity (LIPA). There has been an emergence for seeking an understanding of factors which determine variations in SedT, LIPA, and PAEE. Sedentary behavior and physical activity are relatively resistant to change by experimental dietary treatments and significant body weight changes. Although caffeine ( ...[more]

PMID: 23869233

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Project description:AIMS:Exenatide is a glucagon-like peptide 1 (GLP-1) mimetic which induces weight loss predominantly, it is presumed, via decreased food intake. However, circulating GLP-1 is also a determinant of energy expenditure. We sought to quantify the effect of exenatide on energy expenditure (EE) and energy intake. MATERIALS AND METHODS:In this single-center, randomized double-blind placebo controlled trial, we randomized 80 healthy, non-diabetic volunteers with obesity (46 women, age: 34.4?±?8.7?y, body fat by DXA: 44.2?±?7.8%) to subcutaneous exenatide 10??g twice daily or placebo. Subjects were admitted to our clinical research unit for measurement of 24?h-EE in a whole-room indirect calorimeter and ad libitum food intake using an automated vending machine paradigm before and after randomization. Furthermore, energy expenditure and ad libitum food intake measures were repeated at 24-week after readmission for 7-day inpatient stay. Body weight was obtained weekly for up to 5?weeks and was recorded at each monthly follow up visit up to 24?weeks. RESULTS:Prior to randomization, participants over ate during the 3-day vending machine period in the whole study group (114.6?±?35.2%), expressed as percentage of weight maintaining energy needs (WMEN) with those who were eventually randomized to exenatide overeating more (121.6?±?37.7%) compared to placebo group (107.6?±?31.5%). In the exenatide group, ad libitum absolute energy intake decreased by 1016.1?±?724.5?kcal/day (95% CI: -1250.9 to -781.2) versus a 245.1?±?710.5?kcal/day (95% CI: -475.4 to -14.7) decrease in placebo (??=?-624.8?Kcal/day, p?<?0.0001) whereas the reduction in ad libitum caloric intake relative to WMEN was a more modest 366.8?±?752.1?kcal/day (95% CI: -614.0 to -119.6) decrease compared to 8.0?±?860.1?kcal/day (95% CI: -286.8 to 270.8) reduction in placebo (??=?-382.3?Kcal/day, p?=?0.03). The decrease was uniform across all macronutrients groups. No differences in 24hEE or substrate oxidation rates were found. In the exenatide group, body weight decreased more over the 5?weeks (??=?-0.039?kg/week, p?=?0.02) and was lower compared to placebo at the end of fifth week (-1.48?±?0.77?kg; 95% CI: -3.02 to 0.05, p?=?0.06). At the 24-week follow up, there was no difference in energy intake between exenatide group and placebo group and the treatment group decreased 24-h EE more compared to placebo (??=?-160.6?Kcal/day, 95% CI: -307.6 to 13.6, p?=?0.03) compared to their pre-randomization measurement. However, this reduction was not present after adjustment for changes in FM and FFM (??=?-87?kcal/day, p?=?0.14). No difference was observed in body weight (??=?-1.72?kg, 95% CI: -5.77 to 2.30, p?=?0.39) in exenatide versus placebo over 24?weeks. CONCLUSION:Compared with placebo, exenatide decreased early ad libitum energy intake but did not change 24?h-EE. However, the reduction was more modest in relative versus absolute terms (i.e. below that needed for WMEN). Thus, although rate of weight change was greater in the exenatide treated subjects at 5?weeks, the absolute difference in weight was not significant. These findings indicate that although exenatide reduces food intake, it may be more beneficial in blunting overeating and thus may serve to more prevent weight regain following initial weight loss.

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Dataset Information

Caffeine intake, short bouts of physical activity, and energy expenditure: a double-blind randomized crossover trial.

Publications

Caffeine intake, short bouts of physical activity, and energy expenditure: a double-blind randomized crossover trial.

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