Ontology highlight
ABSTRACT:
SUBMITTER: Fiaschi-Taesch NM
PROVIDER: S-EPMC3712040 | biostudies-literature | 2013 Jul
REPOSITORIES: biostudies-literature
Fiaschi-Taesch Nathalie M NM Kleinberger Jeffrey W JW Salim Fatimah G FG Troxell Ronnie R Wills Rachel R Tanwir Mansoor M Casinelli Gabriella G Cox Amy E AE Takane Karen K KK Srinivas Harish H Scott Donald K DK Stewart Andrew F AF
Diabetes 20130314 7
Harnessing control of human β-cell proliferation has proven frustratingly difficult. Most G1/S control molecules, generally presumed to be nuclear proteins in the human β-cell, are in fact constrained to the cytoplasm. Here, we asked whether G1/S molecules might traffic into and out of the cytoplasmic compartment in association with activation of cell cycle progression. Cdk6 and cyclin D3 were used to drive human β-cell proliferation and promptly translocated into the nucleus in association with ...[more]